Bea Tam trained in the molecular and cell biology of tranferrin and transferrin receptors in Dr. Ross MacGillivray's laboratory at UBC, Vancouver. During this period she gained experience in molecular biology, monoclonal antibody preparation, immunochemistry and enzymology. Her research involved analysis of recombinant transferrin and analysis of its detailed structure. In September of 1997 she joined our lab to study membrane biosynthesis and retinal apoptosis using the transgenic frog model. Her recent results are illustrated here. She is now Research Assistant at the University of British Columbia Vancuver: Beatrice Tam Research Assistant Department of Ophthalmology University of British Columbia, 2550 Willow Street, V5Z 3N9 Vancouver, B.C. Canada E-mail: btam@interchange.ubc.ca

Orson Moritz trained in the molecular and cell biology of the retina in Dr. Robert Molday's laboratory at UBC, Vancuver where he obtained his Ph.D. His thesis research demonstrated the interaction of peripherin/rds and Rom-1 which form crucial partners in the formation of the rim of the rod outer segment disk. In June 1997, he joined our lab as a post-doctoral fellow to conduct studies of membrane biosynthesis and retinal apoptosis using the transgenic frog model. His recent results are illustrated throughout the site, specifically the rhodopsin GFPD334-348, the GFP-rab8, and the GFP-rab8-67L constructs. He become an instructor at department of Neuroscience in 2002 and he is now an Assistant Professor at the University of British Columbia Vancuver: Orson Moritz, PhD Assistant Professor Department of Ophthalmology University of British Columbia, 2550 Willow Street, V5Z 3N9 Vancouver, B.C. Canada. E-mail: olmoritz@interchange.ubc.ca.

Dr. David Papermaster has been the Solomon Professor of Vision Research and Eye Diseases in the Program in Neuroscience in the Department of Pharmacology at the University of Connecticut Health Center in Farmington since April 1997. In January 1997 he was a Visiting Scientist at Harvard Medical School in the lab of Dr. Marc Kirchner working with Dr. Kris Kroll on her new technique for generating transgenic frogs. From 1986-1997 he was Professor of Pathology and of Cellular & Structural Biology at University of Texas Health Science Center at San Antonio and was Chairman of Pathology from 1986 to 1994 at which time he resigned chair to resume full time research and teaching. For the prior 15 years he was in the Department of Pathology at Yale Medical School. He obtained his AB in history at Harvard College and his MD at Harvard Medical School, and trained in immunochemistry with Tom Gill, in membrane biochemistry with Don Wallach at MGH, and trained in Pathology at PBBH, Boston. His postdoctoral training was in protein chemistry and developmental biology at Caltech with Bill Dreyer where he began vision research in 1969. During 1976-77 he was a Josiah Macy Scholar on sabbatical leave at the Weizmann Institute, Rehovot, Israel, where he isolated opsin's mRNA and sequenced the translation product with Israel Schechter's group. He has published over 160 papers and abstracts, primarily on retinal membrane biosynthesis and protein localization at the EM level and more recently on the molecular biology and pathology of retinal degeneration and apoptosis.

Recent Publications are Listed Below

Papermaster, DS. Necessary but insufficient: Mutations of genes do not explain why neurons die. Nature- Medicine 1: 874-875 (1995).

Deretic D, Huber LA, Ransom N, Mancini M, Simons K and Papermaster DS. Rab8 in retinal photoreceptors may participate in rhodopsin transport and in rod outer segment morphogenesis J Cell Sci 108:215-224(1995).

de Turco EBR, Deretic D, Bazan NG, and Papermaster DS. Post-Golgi Vesicles Cotransport Docosahexaenoyl-Phospholipids and Rhodopsin during Frog Photoreceptor Membrane Biogenesis J Biol Chem 272, 10491-10497 (1997)

Papermaster, DS. Apoptosis of the retina and lens. Cell Death and Differentiation. 4:21-28 (1997)

Hopp, RMP, Ransom, N, Hilsenbeck, SG, Papermaster, DS and Windle, JJ. Apoptosis in the Murine rd1 Retinal Degeneration is Predominantly p53-Independent pathway. Molecular Vision 4: 5-9, 1998
http://www.emory.edu/molvis/v4/p5

Papermaster, D.S. Apoptosis of tissues of the eye during development and disease. In "When Cells Die". Lockshin, R.A., Zakeri, Z. F. and Tilly, J. eds. Wiley-Liss, New York, NY. 1998 pp. 321-346

Ma, C, Papermaster, DS. and Cepko, CL. A novel pattern of photoreceptor degeneration in cyclin D1 mutant mice. Proc Natl Acad Sci U S A 95:9938-9943 (1998)

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